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Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study PDF Print E-mail
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Friday, 01 October 2004 00:00
“The effect of coffee consumption on the cardiovascular system is conflicting. Inflammation is important to the development of cardiovascular disease (CVD), and several dietary factors are thought to exert significant effect on inflammation and thus on the risk of CVD.”

“The cross-sectional survey enrolled 1514 men (aged 46 +/- 13 y; range 18-87 y) and 1528 women (aged 45 +/- 13 y; range 18-89 y).”

“Studies have suggested that low-grade systemic inflammation participates in the pathophysiology of obesity, insulin resistance, ischemic heart disease, metabolic syndrome X, and abnormal coagulation process. An extensive body of scientific evidence also suggests that dietary factors exert their influence largely through their effects on blood pressure, lipids and lipoproteins, as well as on markers of inflammation and coagulation. This evidence implies that dietary intervention designed to reduce the inflammatory process could be of benefit in reducing the risk of cardiovascular disease (CVD).”

“All inflammatory markers showed a linear dose-response relation (P < 0.01) with coffee consumption. Compared with coffee nondrinking men, those men who consumed > 200 mL coffee/d had an average 30% higher CRP [C-reactive Protein], 50% higher IL-6 [Interleukin], 12% higher SAA [Serum Amyloid-A], and 28% higher TNF-α [Tumor Necrosis Factor] and only 3% higher WBC [White Blood Cell] counts (NS). Similiarly, a women who consumed > 200 mL coffee/d had an average 38% higher CRP, 54% higher IL-6, 28% higher SAA, and 28% higher TNF-α and only 4% higher WBC counts (NS) than did coffee nondrinkers.”

“The effect of coffee consumption on inflammation marker concentrations was investigated in 3042 randomly selected men and women from the region of Attica in Greece. Coffee drinking was associated with an increase in all inflammatory markers investigated, but the difference was significant only when participants who consumed > 200 mL coffee/d were compared with participants who did not drink coffee. A variant association of coffee intake with blood pressure levels was also observed. A positive association between coffee consumption and presence of hypercholesterolemia in both sexes was found.”

“In recent years, clinical and observational studies reported that coffee consumption was associated with cardiac arrhythmia, heart rate serum cholesterol, blood pressure, and consequently cardiovascular risk.”

“Note that the association observed in the present study between coffee consumption and the inflammatory markers was linear, reaching statistical significance only when > 200 mL coffee/d was consumed. Coffee intake of 200 mL represents approx. 1 cup; therefore, the results presented here suggest that the increase in the inflammatory markers could be evident even with 2 cups coffee/d.”

“Elevated plasma homocysteine concentrations are also observed with the consumption of unfiltered coffee, but a possible proinflammatory effect of these substances remains to be elucidated.”

“Caffeine could be the most frequently ingested pharmacologically active substance globally. Because of its wide consumption at different amounts by most segments of the population, evaluation of the effects of coffee consumption on various cardiovascular markers should be of great importance from a public health perspective. We observed here that even moderate consumption of unfiltered coffee increases the amounts of proinflammatory markers of ischemic heart disease. These findings might suggest another pathobiological mechanism by which coffee consumption could influence coronary risk. Metabolic studies are needed to confirm our findings, with the outcome being a stronger public health message.”


Antonios Zampelas, Demosthenes B Panagiotakos, Chritos Pitsavos, Christian Chyrsohoou, and Christodoulos Stefanadis, "Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study", American Journal of Clinical Nutrition, October 1, 2004, Vol. 80, Num. 0, pp. 862-867

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Last Updated on Wednesday, 24 June 2009 13:05