|Childhood Cancer Leaves Cardiac Legacy|
|Monday, 26 July 2010 00:00|
An alarmingly high percentage of childhood cancer survivors have abnormal cardiac function even in early adulthood, a long-term Dutch study found.
By age 23, 27% of five-year survivors had subclinical cardiac dysfunction, as shown by left ventricular (LV) shortening fraction below 30%, Helena J. van der Pal, MD, of Emma Children's Hospital in Amsterdam, and colleagues, reported in the July 26 issue of Archives of Internal Medicine.
Multivariate linear regression analysis determined the following factors to be significantly associated with a change in LV shortening fraction:
* Age at diagnosis, P=0.049
Late treatment effects, including cardiotoxicity, are well recognized among childhood cancer survivors, and suspected risk factors include dose and type of anthracycline and radiation dose.
However, previous studies of long-term outcomes for these children have had conflicting results and have not estimated the impact of other potentially cardiotoxic drugs such as high-dose cyclophosphamide.